| Identification | Back Directory | [Name]
rac-8-(((R)-1-((2R,4S)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-8-oxooctanoic acid | [CAS]
2172819-75-7 | [Synonyms]
(S,R,S)-AHPC-amido-C6-acid
8-(((S)-1-((2S,4R)-4-Hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamido)-3,3-dimethyl-1-oxobutan-2-yl)amino)-8-oxooctanoic acid
8-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-8-oxooctanoic acid
rac-8-(((R)-1-((2R,4S)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-8-oxooctanoic acid | [Molecular Formula]
C30H42N4O6S | [MDL Number]
MFCD33022218 | [MOL File]
2172819-75-7.mol | [Molecular Weight]
586.74 |
| Chemical Properties | Back Directory | [Boiling point ]
884.7±65.0 °C(Predicted) | [density ]
1.242±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [pka]
4.77±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
(S,R,S)-AHPC-amido-C6-acid is a VHL ligand with a 6 carbon alkyl linker and terminal acid for PROTAC compounds. | [Uses]
VH 032 amide-alkylC6-acid ((S,R,S)-AHPC-CO-C6-COOH) is a VH032 analog that acts as a ligand for VHL, recruiting von Hippel-Lindau (VHL) protein. VH 032 amide-alkylC6-acid can be used in the synthesis of PROTACs[1]. | [IC 50]
VHL | [storage]
Store at -20°C | [References]
[1] Jian Jin, et al. Compositions and methods for treating ezh2-mediated cancer, WO2018081530A1. |
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