2245697-83-8

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2245697-83-8 Structure

Identification	Back Directory
[Name] Protac linker 5
[CAS] 2245697-83-8
[Synonyms] Protac linker 5 (S,R,S)-AHPC-C3-NH2 VH032-C4-NH2 hydrochloride VHL Ligand-Linker Conjugates 13 E3 ligase Ligand-Linker Conjugates 28
[Molecular Formula] C27H40ClN5O4S
[MDL Number] MFCD31656716
[MOL File] 2245697-83-8.mol
[Molecular Weight] 566.16

Chemical Properties	Back Directory
[form ] Solid
[color ] Light yellow to green yellow

Hazard Information	Back Directory
[Uses] (S,R,S)-AHPC-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC[1].
[IC 50] VHL
[References] [1] Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9. DOI:10.1016/j.chembiol.2019.11.004

Spectrum Detail	Back Directory
[Spectrum Detail] Protac linker 5(2245697-83-8)¹HNMR

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