| Identification | Back Directory | [Name]
L-Prolinamide, N-(10-carboxy-1-oxodecyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- | [CAS]
2172819-78-0 | [Synonyms]
MDN19780
VH032-NH-CO-C9-acid
(S,R,S)-AHPC-CO-C9-acid
L-Prolinamide, N-(10-carboxy-1-oxodecyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- | [Molecular Formula]
C33H48N4O6S | [MOL File]
2172819-78-0.mol | [Molecular Weight]
628.82 |
| Chemical Properties | Back Directory | [Boiling point ]
897.0±65.0 °C(Predicted) | [density ]
1.205±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.78±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
MDN19780 is a Functionalized von-Hippel-Lindau protein (VHL) ligand for PROTAC? research and development. It incorporates an E3 ligase ligand plus an alkylC9 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. MDN19780 is Part of a range of functionalized tool molecules for PROTAC R&D. This product has no formal name. | [Uses]
(S,R,S)-AHPC-CO-C9-acid is an E3 ligase ligand-linker conjugate that can be connected to the ligand for protein to form PROTACs. | [storage]
Store at -20°C | [References]
[1] Xu J, et al. AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B. Cancer Discov. 2021 Jul 23. DOI:10.1158/2159-8290.CD-20-0815 |
|
|