| Identification | Back Directory | [Name]
L-Lysine, N-[[[(1S)-2-[(4-nitrophenyl)amino]-2-oxo-1-(phenylmethyl)ethyl]amino]carbonyl]-D-norleucyl-, methyl ester | [CAS]
217480-25-6 | [Synonyms]
778
L796
L-796
L 796
L-796778
L-Lysine, N-[[[(1S)-2-[(4-nitrophenyl)amino]-2-oxo-1-(phenylmethyl)ethyl]amino]carbonyl]-D-norleucyl-, methyl ester | [Molecular Formula]
C29H40N6O7 | [MOL File]
217480-25-6.mol | [Molecular Weight]
584.66 |
| Chemical Properties | Back Directory | [Boiling point ]
868.8±65.0 °C(Predicted) | [density ]
1.239±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.36±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
L-796,778 is bioactive chemical. | [Uses]
L-796778 is an agonist of the hsst3 receptor. In CHO-K1 cells expressing the hsst3 receptor, L-796778 is a partial agonist that inhibits forskolin (HY-15371)-stimulated cAMP production with an IC50 value of 18 nM[1]. | [Definition]
ChEBI: L-796,778 is a methyl ester resulting from the formal condensation of the carboxy group of N-{[(2S)-1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-D-norleucyl-L-lysine with methanol. It is a partial agonist of somatostatin subtype receptor 3 (Ki = 24 nM) that exhibits anticonvulsant effects. It has a role as a somatostatin receptor agonist. It is a methyl ester, a C-nitro compound, a member of ureas, a L-phenylalanine derivative, a L-lysine derivative, a secondary carboxamide, a member of benzenes and an oligopeptide. | [IC 50]
SSTR3 | [References]
[1] Pfeiffer M,et al. Homo- and heterodimerization of somatostatin receptor subtypes. Inactivation of sst(3) receptor function by heterodimerization with sst(2A). J Biol Chem. 2001 Apr 27;276(17):14027-36. DOI:10.1074/jbc.M006084200 |
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