| Identification | Back Directory | [Name]
(4E)-TCO-PEG4-biotin | [CAS]
2183440-30-2 | [Synonyms]
Biotin-PEG4-TCO
TCO-PEG4-biotin
(4E)-TCO-PEG4-biotin | [Molecular Formula]
C29H50N4O8S | [MDL Number]
MFCD31561115 | [MOL File]
2183440-30-2.mol | [Molecular Weight]
614.79 |
| Chemical Properties | Back Directory | [Boiling point ]
837.0±65.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [pka]
11.95±0.46(Predicted) |
| Hazard Information | Back Directory | [Description]
TCO-PEG4-biotin is a biotinylation reagent containing TCO moieties. TCO enable click chemistry with tetrazine. The hydrophilic PEG spacer improves the water solubility of compounds. | [Uses]
TCO-PEG4-biotin is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. DOI:10.1016/j.apsb.2019.08.001 |
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