ChemicalBook--->CAS DataBase List--->2222687-71-8

2222687-71-8

2222687-71-8 Structure

2222687-71-8 Structure
IdentificationBack Directory
[Name]

Biotin-PEG4- Picolyl Azide
[CAS]

2222687-71-8
[Synonyms]

Biotin-PEG4- Picolyl Azide
[Molecular Formula]

C27H42N8O7S
[MDL Number]

MFCD29052186
[MOL File]

2222687-71-8.mol
[Molecular Weight]

622.74
Chemical PropertiesBack Directory
[form ]

Oil
[color ]

Colorless to off-white
Hazard InformationBack Directory
[Description]

Biotin-PEG4-Picolyl azide is a biotin reagent which can be conjugated with alkyne-containing biomolecules. This biotin reagent incorporates a copper-chelating motif that dramatically accelerates the Cu(I)-catalyzed Click Chemistry. The use of Biotin Picolyl Azide instead of conventional Biotin Azide allows for at least a tenfold reduction in the concentration of the copper catalyst without sacrificing the efficiency of labeling. The hydrophilic spacer arm provides better solubility to the labeled molecules in aqueous media.
[Uses]

Biotin-PEG4-Picolyl azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Biotin-PEG4-Picolyl azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
[IC 50]

PEGs
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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