| Identification | Back Directory | [Name]
podocarpusflavone A | [CAS]
22136-74-9 | [Synonyms]
podocarpusflavone A
Podocurpusflavone A
4',5,5'',7,7''-Pentahydroxy-4'''-methoxy-3',8''-biflavone
8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-
8-[5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
2-(4-Methoxyphenyl)-8-[2-hydroxy-5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one
2-(4-Methoxyphenyl)-8-[6-hydroxy-3-(4-oxo-5,7-dihydroxy-4H-1-benzopyran-2-yl)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)- | [Molecular Formula]
C31H20O10 | [MDL Number]
MFCD03844824 | [MOL File]
22136-74-9.mol | [Molecular Weight]
552.48 |
| Chemical Properties | Back Directory | [Boiling point ]
879.3±65.0 °C(Predicted) | [density ]
1.576±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: soluble; Ethanol: soluble | [form ]
A solid | [pka]
5.99±0.40(Predicted) | [color ]
Light yellow to green yellow |
| Hazard Information | Back Directory | [Uses]
Podocarpusflavone A is a DNA topoisomerase I inhibitor. Podocarpusflavone A has moderated anti-proliferative activity and induces cell apoptosis in MCF-7. Podocarpusflavone A is developing anti-tumor agents[1]. | [Definition]
ChEBI: Podocarpusflavone a is a flavonoid oligomer. | [IC 50]
Topoisomerase I: 119.425 μM (IC50) | [storage]
Store at -20°C | [References]
[1] Pen-Ho Yeh et al. Naturally Occurring Cytotoxic [3′→8″]-Biflavonoids from Podocarpus nakaii
J Tradit Complement Med. 2012 Jul;2(3):220-6. DOI:10.1016/s2225-4110(16)30103-1 |
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