| Identification | Back Directory | [Name]
chikusetsu saponin IVa | [CAS]
51415-02-2 | [Synonyms]
Glycoside D2
Momordin IIb
Silphioside G
Calenduloside F
Hericiumsaponin S1
Chikusetsu saponin Ⅳa
chikusetsu saponin IVa
Chikusetsusaponin Iva (Calenduloside F)
28-(β-D-Glucopyranosyloxy)-28-oxoolean-12-en-3β-yl β-D-glucopyranosiduronic acid
b-D-Glucopyranosiduronic acid, (3b)-28-(b-D-glucopyranosyloxy)-28-oxoolean-12-en-3-yl
β-D-Glucopyranosiduronic acid, (3β)-28-(β-D-glucopyranosyloxy)-28-oxoolean-12-en-3-yl
Chikusetsusaponin IVA, 98%, from Panax pseudoginseng Wall. var. japonicus (C. A. Mey.) Hoo et Tseng | [Molecular Formula]
C42H66O14 | [MDL Number]
MFCD22125022 | [MOL File]
51415-02-2.mol | [Molecular Weight]
794.97 |
| Chemical Properties | Back Directory | [Melting point ]
218-220℃ (methanol , water ) | [Boiling point ]
873.3±65.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
2-8°C | [solubility ]
DMSO : 100 mg/mL (125.79 mM; Need ultrasonic) | [form ]
powder | [pka]
2.82±0.70(Predicted) | [color ]
White-off-white | [InChIKey]
YOSRLTNUOCHBEA-SGVKAIFKSA-N |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Panax notoginseng. | [Uses]
Chikusetsusaponin Iva is the main active component of triterpenoid saponins, acts as an activator of protein kinases, and has a resistance effect against thrombosis and some metabolic diseases. | [Definition]
ChEBI: A natural product found in Panax japonicus var. major. | [References]
[1] Wang H, et al.Inhibitory effects of Chikusetsusaponin IVa on lipopolysaccharide-induced pro-inflammatory responses in THP-1 cells. Int J Immunopathol Pharmacol. 2015 Jul 8. DOI:10.1177/0394632015589519
[2] Cui J, et al. Insulinotropic effect of Chikusetsu saponin IVa in diabetic rats and pancreatic β-cells. J Ethnopharmacol. 2015 Apr 22;164:334-9. DOI:10.1016/j.jep.2015.02.032
[3] Li Y, et al. Chikusetsu saponin IVa regulates glucose uptake and fatty acid oxidation: implications in antihyperglycemic and hypolipidemic effects. J Pharm Pharmacol. 2015 Jul;67(7):997-1007. DOI:10.1111/jphp.12392
[4] Dahmer T, et al. Antithrombotic effect of chikusetsusaponin IVa isolated from Ilex paraguariensis (Maté). J Med Food. 2012 Dec;15(12):1073-80. DOI:10.1089/jmf.2011.0320 |
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