| Identification | Back Directory | [Name]
HYPOCRELLIN A | [CAS]
77029-83-5 | [Synonyms]
HYPOCRELLIN
HYPOCRELLIN A
(1S,2R)-1-acetyl-2,5,12-trihydroxy-4,8,9,13-tetramethoxy-2-m...
(1S,2R)-1-acetyl-2,5,12-trihydroxy-4,8,9,13-tetramethoxy-2-methyl-2,3-dihydro-1H-cyclohepta[ghi]perylene-6,11-dione
1H-Cyclohepta[ghi]perylene-5,12-dione,1-acetyl-2,3-dihydro-2,6,11-trihydroxy-4,8,9,13-tetramethoxy-2-methyl-,stereoisomer
(11R,12S)-11-acetyl-3,9,12-trihydroxy-1,5,6,10-tetramethoxy-12-methyl-12,13-dihydro-2H-cyclohepta[ghi]perylene-2,8(11H)-dione | [Molecular Formula]
C30H26O10 | [MDL Number]
MFCD00467740 | [MOL File]
77029-83-5.mol | [Molecular Weight]
546.52 |
| Chemical Properties | Back Directory | [Melting point ]
209-210 °C | [Boiling point ]
922.8±65.0 °C(Predicted) | [density ]
1.55±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMF: 2mg/mL; DMSO: 3mg/mL; Ethanol: 0.3mg/mL | [form ]
A solid | [pka]
7.03±0.60(Predicted) | [color ]
Brown to red |
| Hazard Information | Back Directory | [Uses]
Hypocrellin A is an antimicrobial and antileishmanial activity. Ga(3+)-Hypocrellin interacts with myoglobin in vitro. | [in vivo]
Hypocrellin A (2.5 and 5 mg/kg; i.p.; once every two days for fourteen days) inhibits tumor growth in a non-small cell lung cancer xenograft model mouse model[8]. | Animal Model: | H460 cells were inoculated subcutaneously on the backs of BALB/c nude mice[8] | | Dosage: | 2.5 and 5 mg/kg | | Administration: | i.p.; Inject once every two days for fourteen days | | Result: | Induced the expression of the pro-apoptotic protein BAX and inhibited the expression of the anti-apoptotic protein BCL-2 in NSCLC tumors. |
| [IC 50]
Leishmania | [storage]
4°C, protect from light |
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