| Chemical Properties | Back Directory | [density ]
1.369±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 250 mg/mL (624.34 mM; Need ultrasonic) | [form ]
Solid | [pka]
7.26±0.25(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
WM-3835 is a potent and high-specific HBO1 (KAT7 or MYST2) inhibitor and binds directly to the acetyl-CoA binding site of HBO1. WM-3835 activates apoptosis while inhibits osteosarcoma (OS) cell proliferation, migration and invasion. WM-3835 has antitumor activity and potently inhibits pOS-1 xenograft growth in mice[1]. | [Biological Activity]
WM-3835is a cell-permeable hydroxybenzenesulfonohydrazide compound th at acts as a potentselectiveAc-CoA competitive and reversible inhibitor of HBO1KAT6A and TIP60 acetyltransferases (IC50 = 0.0300.017 and 0.312 μMrespectively). WM-3835 is non-cytotoxicdose-dependentlyand rapidly decreases H3K14Ac levels (IC50 = 0.341 μM) and inhibits AML cells growth (IC50 = 0.297 μM in Molm13). Induces apoptosisdownregulates HOXA and IL-6 expression and up-regulates ALB secretion and delays hepatocyte and hMPC senescence. WM-1385 potently inhibits POS-1 xenograft growth in SCID mice (10 mg/kgi.p.). | [in vivo]
WM-3835 (10 mg/kg/day; ip; for21 days) potently inhibits pOS-1 xenograft growth in SCID mice[1].
| Animal Model: | SCID mice (18-19 g, female) with pOS1 cells[1] | | Dosage: | 10 mg/kg | | Administration: | IP; daily; for 21 days | | Result: | Potently inhibited pOS-1 xenograft growth.
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| [IC 50]
HBO1 | [storage]
4°C, protect from light | [References]
[1] Yan-Yang Gao, et al. The histone acetyltransferase HBO1 functions as a novel oncogenic gene in osteosarcoma. Theranostics. 2021 Mar 4;11(10):4599-4615. DOI:10.7150/thno.55655 |
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