| Identification | Back Directory | [Name]
(S,R,S)-AHPC-Me-C5-COOH | [CAS]
2229976-21-8 | [Synonyms]
(S,R,S)-AHPC-Me-C5-COOH
L-Prolinamide, N-(6-carboxy-1-oxohexyl)-3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- | [Molecular Formula]
C30H42N4O6S | [MDL Number]
MFCD33029229 | [MOL File]
2229976-21-8.mol | [Molecular Weight]
586.74 |
| Chemical Properties | Back Directory | [Boiling point ]
876.0±65.0 °C(Predicted) | [density ]
1.240±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
Solid | [pka]
4.75±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
(S,R,S)-AHPC-Me-C5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C5-COOH can be used in PROTAC DT2216 (HY-130604)[1]. | [IC 50]
VHL | [References]
[1] Khan S, et al. A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nat Med. 2019 Dec;25(12):1938-1947. DOI:10.1038/s41591-019-0668-z |
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