| Identification | Back Directory | [Name]
6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid | [CAS]
2172819-74-6 | [Synonyms]
VH 032-linker 5
VH 032 amide-alkylC4-acid
(S,R. S)-AHPC-pentanoic-acid
6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid | [Molecular Formula]
C28H38N4O6S | [MDL Number]
MFCD32693310 | [MOL File]
2172819-74-6.mol | [Molecular Weight]
558.69 |
| Chemical Properties | Back Directory | [Boiling point ]
878.5±65.0 °C(Predicted) | [density ]
1.272±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO, DMF | [form ]
Solid | [pka]
4.70±0.10(Predicted) | [color ]
white to light yellow | [InChIKey]
DKSZOQIYZOVHOL-TYBLODHISA-N | [SMILES]
C([C@@H](NC(CCCCC(O)=O)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1 |
| Hazard Information | Back Directory | [Description]
(S, R, S)-AHPC-pentanoic-acid is a PROTAC linker that incorporate an E3 ligase ligand with a linker to empower PROTAC drug research & discovery. It can react with amine containing molecules. | [Uses]
(S,R,S)-AHPC-C4-COOH (VH032-C4-COOH) (linker 45) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-targeted PROTAC[1]. | [storage]
Store at -20°C | [References]
[1] Liu Jing, et al. Preparation of pyrazolopyridines and related heterocycles as CBP and p300 degradation bivalent compds for treatment of diseases. World Intellectual Property Organization, WO2020173440 A1 2020-09-03 |
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ChemShuttle, Inc.
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