| Chemical Properties | Back Directory | [Boiling point ]
1141.7±65.0 °C(Predicted) | [density ]
1.324±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO|103.06|100| | [form ]
Solid | [pka]
13.54±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
SJF 1528 is a potent EGFR Degrader. It also degrades HER2. | [Uses]
SJF-1528 is a potent EGFR PROTAC degrader with DC50 values of 39.2 nM and 736.2 nM for wild-type EGFR in OVCAR8 cells and Exon 20 Ins mutated EGFR in HeLa cells. SJF-1528 also degrades HER2 (Pink: ligand for target protein (HY-159047); Black: linker Tos-PEG2-CH2-Boc (HY-130532); Blue: ligand for E3 ligase (S,R,S)-AHPC (HY-125845))[1]. | [storage]
Store at -20°C | [References]
[1] Burslem GM, et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3. DOI:10.1016/j.chembiol.2017.09.009 |
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