| Identification | Back Directory | [Name]
Gefitinib-based PROTAC 3 | [CAS]
2230821-27-7 | [Synonyms]
NTN21277
Gefitinib-based PROTAC 3
NTN21277(Gefitinib-based PROTAC 3) | [Molecular Formula]
C47H57ClFN7O8S | [MOL File]
2230821-27-7.mol | [Molecular Weight]
934.52 |
| Chemical Properties | Back Directory | [Boiling point ]
1065.6±65.0 °C(Predicted) | [density ]
1.300±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [solubility ]
DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml; DMSO: 16 mg/ml; Ethanol: 10 mg/ml | [form ]
A crystalline solid | [pka]
14.07±0.40(Predicted) | [color ]
Off-white to light yellow | [InChIKey]
NICKHWYZMNLEPJ-OMWXADOMNA-N | [SMILES]
N(C1C=CC(F)=C(Cl)C=1)C1=NC=NC2C=C(OC)C(OCCCCCOCCOCCC(=O)N[C@@H](C(C)(C)C)C(N3C[C@H](O)C[C@H]3C(=O)NCC3C=CC(C4=C(N=CS4)C)=CC=3)=O)=CC1=2 |&1:34,42,45,r| |
| Hazard Information | Back Directory | [Description]
Gefitinib-based PROTAC 3 contains an EGFR binding element and a von Hippel-Lindau ligand joined by a linker which induces EGFR degradation. | [Uses]
Gefitinib-based PROTAC 3 is useful for EGFR proteolysis targeting. | [IC 50]
EGFR: 11.7 nM (DC50, HCC827(exon 19 del) cells); EGFR: 22.3 nM (DC50, H3255 (L858R mutantion) cells); PROTAC | [storage]
4°C, away from moisture and light |
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