| Identification | Back Directory | [Name]
Homo-PROTAC cereblon degrader 1 | [CAS]
2244520-98-5 | [Synonyms]
Homo-PROTAC cereblon degrader 1 | [Molecular Formula]
C32H32N6O10 | [MDL Number]
MFCD31813818 | [MOL File]
2244520-98-5.mol | [Molecular Weight]
660.64 |
| Chemical Properties | Back Directory | [Boiling point ]
978.5±65.0 °C(Predicted) | [density ]
1.527±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 200 mg/mL (302.74 mM) | [form ]
Solid | [pka]
10.44±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
Homo-PROTAC Cereblon Degrader 1 is a highly potent and efficient Cereblon (CRBN) degrader with minimal effects on IKZF1 and IKZF3. | [Uses]
Homo-PROTAC cereblon degrader 1 (compound 15a) is a highly potent and efficient Cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3[1]. | [IC 50]
Cereblon | [References]
[1] Steinebach C, et al. Homo-PROTACs for the Chemical Knockdown of Cereblon. ACS Chem Biol. 2018 Sep 21;13(9):2771-2782. DOI:10.1021/acschembio.8b00693 |
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