| Identification | Back Directory | [Name]
4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | [CAS]
1818885-63-0 | [Synonyms]
Cereblon Ligand-Linker Conjugates 9
E3 Ligase Ligand-Linker Conjugates 2
4-[2-[2-[2-[2-(4-aminophenoxy)ethoxy]ethoxy]ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-[2-[2-(4-aminophenoxy)ethoxy]ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)- | [Molecular Formula]
C27H32N4O8 | [MOL File]
1818885-63-0.mol | [Molecular Weight]
540.57 |
| Chemical Properties | Back Directory | [Boiling point ]
792.0±60.0 °C(Predicted) | [density ]
1.363±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
Solid | [pka]
10.74±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
Pomalidomide-PEG4-Ph-NH2 is comprised of the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. Pomalidomide-PEG4-Ph-NH2 is used in PROTAC technology as a E3 ligase ligand-linker conjugate that incorporates PEG technology that can be linked to a wide range of "warheads" that bind to proteins of interest. | [Uses]
Pomalidomide-PEG4-Ph-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. | [IC 50]
Cereblon | [References]
[1] Andrew P. Crew, et al. Imide-based modulators of proteolysis and associated methods of use. US20160058872A1. |
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| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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