| Chemical Properties | Back Directory | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMSO:250.0(Max Conc. mg/mL);387.18(Max Conc. mM) | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM). LIT-001 improves social interaction in a mouse model of autism[1]. | [in vivo]
LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD )[1]. | Animal Model: | Oprm1–/– mice (bred in house on a 50% 129SVPas–50% C57BL/6J hybrid background)[1] | | Dosage: | 10, 20 mg/kg | | Administration: | i.p. | | Result: | Alleviated core symptoms in the context of ASD. |
| [storage]
Store at -20°C | [References]
[1] Frantz MC, et al. LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism. J Med Chem. 2018 Oct 11;61(19):8670-8692. DOI:10.1021/acs.jmedchem.8b00697 |
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