| Identification | Back Directory | [Name]
t-Boc-Aminooxy-PEG5-azide | [CAS]
2250216-95-4 | [Synonyms]
Boc Aminooxy-PEG5-Azide
t-Boc-Aminooxy-PEG5-azide | [Molecular Formula]
C17H34N4O8 | [MDL Number]
MFCD31811536 | [MOL File]
2250216-95-4.mol | [Molecular Weight]
422.48 |
| Hazard Information | Back Directory | [Description]
t-Boc-Aminooxy-PEG5-azide is a PEG5 compound with an azide group and Boc-protected amino group. It is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
t-Boc-Aminooxy-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. t-Boc-Aminooxy-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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