| Identification | Back Directory | [Name]
TCO-PEG3-amide-C3-triethoxysilane | [CAS]
2250217-32-2 | [Synonyms]
TCO-PEG3-amide-C3-triethoxysilane | [Molecular Formula]
C27H52N2O9Si | [MDL Number]
MFCD31811541 | [MOL File]
2250217-32-2.mol | [Molecular Weight]
576.8 |
| Chemical Properties | Back Directory | [Boiling point ]
660.1±55.0 °C(Predicted) | [density ]
1.08±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [pka]
11.95±0.46(Predicted) |
| Hazard Information | Back Directory | [Description]
TCO-PEG3-triethoxysilane is a crosslinking PEG reagent containing a triethoxysilane moiety and a TCO group. Triethoxysilane is commonly used for surface modifications. This reagent can react with tetrazine-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. | [Uses]
TCO-PEG3-amide-C3-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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