| Identification | Back Directory | [Name]
5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine | [CAS]
2253745-78-5 | [Synonyms]
5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine | [Molecular Formula]
C27H25F2N3O | [MOL File]
2253745-78-5.mol | [Molecular Weight]
445.5 |
| Hazard Information | Back Directory | [Description]
5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC50s = 66 and 2,730 nM for the human and mouse enzymes, respectively).1 It is selective for mPGES-1 over COX-1 but does inhibit COX-2 at 20 μM. It also inhibits LPS-induced prostaglandin E2 (PGE2; ) production in mouse peritoneal cells (IC50 = 12 nM). In vivo, 5-butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine (25 mg/kg) reduces carrageenan-induced paw edema in rats. | [References]
1. Kal?ic, F., Kolman, V., Ajani, H., et al. Polysubstituted pyrimidines as mPGES-1 inhibitors: Discovery of potent inhibitors of PGE2 production with strong anti-inflammatory effects in carrageenan-induced rat paw edema ChemMedChem 15(15),1398-1407(2020). |
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ChemeGen
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18818260767 |
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https://www.chemegen.com |
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