| Identification | More | [Name]
1,3-Difluoro-5-iodobenzene | [CAS]
2265-91-0 | [Synonyms]
1,3-DIFLUORO-5-IODOBENZENE
3,5-DIFLUOROIODOBENZENE
3,5-Difluoroiodobenzene 98%
3,5-Difluoroiodobenzene98%
BENZENE,1,3-DIFLUORO-5-IODO | [EINECS(EC#)]
607-122-9 | [Molecular Formula]
C6H3F2I | [MDL Number]
MFCD03094155 | [Molecular Weight]
239.99 | [MOL File]
2265-91-0.mol |
| Chemical Properties | Back Directory | [Boiling point ]
173-174 °C(lit.) | [density ]
2.004 | [refractive index ]
n20/D 1.5540(lit.)
| [Fp ]
180 °F
| [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
clear liquid | [color ]
Colorless to Light yellow to Light orange | [Sensitive ]
Light Sensitive | [BRN ]
2041185 | [CAS DataBase Reference]
2265-91-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
1993 | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29039990 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless or yellow liquid | [General Description]
3,5-Difluoroiodobenzene is an asymmetric top molecule. 3,5-Difluoroiodobenzene reacts with magnesium turnings in the presence of a minimum amount of ether to afford the corresponding Grignard reagent. This reagent is employed in the synthesis of tris(3,5-difluorophenyl)methanol. | [Synthesis]
General procedure for the synthesis of 1,3-difluoro-5-iodobenzene from 3,5-difluorophenylboronic acid: 0.05 mmol of Cu(NO3)2-3H2O, 1 mmol of I2, 1 mmol of 3,5-difluorophenylboronic acid, and 0.8 mL of acetonitrile were added to a 15 mL reaction tube. The reaction tube was sealed and the reaction was carried out under no inert gas protection for 6 hours. Upon completion of the reaction, the reaction was terminated by adding 10 mL of water. The mixture was extracted with dichloromethane (3 x 15 mL). The organic layers were combined, washed sequentially with aqueous sodium thiosulfate and distilled water, dried over anhydrous Na2SO4, filtered and concentrated. The crude product was purified by column chromatography and structurally characterized by 1H NMR, 13C NMR or GC-MS. | [References]
[1] Catalysis Communications, 2013, vol. 32, p. 15 - 17 |
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