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2276672-04-7

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2276672-04-7 Structure

2276672-04-7 Structure
IdentificationBack Directory
[Name]

Biotin-PEG11-CH2CH2N3
[CAS]

2276672-04-7
[Synonyms]

Biotin-PEG11-CH2CH2N3
[Molecular Formula]

C34H64N6O13S
[MOL File]

2276672-04-7.mol
[Molecular Weight]

796.98
Hazard InformationBack Directory
[Biological Activity]

Biotin-PEG11-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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