| Identification | More | [Name]
3-Hydroxy-2-iodo-6-methylpyridine | [CAS]
23003-30-7 | [Synonyms]
2-IODO-6-METHYL-3-HYDROXYPYRIDINE
2-IODO-6-METHYL-3-PYRIDINOL
3-HYDROXY-2-IODO-6-METHYLPYRIDINE
6-IODO-2-PICOLIN-5-OL
2-IODO-3-HYDROXY-6-PICOLINE
3-Hydroxy-2-iodo-6-
6-IODO-2-PICOLIN-5-OL 97%
2-Iodo-6-methyl-3-pyridinol, 6-Iodo-2-picolin-5-ol | [EINECS(EC#)]
245-376-9 | [Molecular Formula]
C6H6INO | [MDL Number]
MFCD00006246 | [Molecular Weight]
235.02 | [MOL File]
23003-30-7.mol |
| Chemical Properties | Back Directory | [Appearance]
Light yellow to yellow powder | [Melting point ]
197-199 °C (lit.) | [Boiling point ]
292.0±35.0 °C(Predicted) | [density ]
1.8615 (estimate) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [pka]
5.46±0.10(Predicted) | [InChI]
InChI=1S/C6H6INO/c1-4-2-3-5(9)6(7)8-4/h2-3,9H,1H3 | [InChIKey]
HRZOWBGCOJWHDY-UHFFFAOYSA-N | [SMILES]
C1(I)=NC(C)=CC=C1O | [CAS DataBase Reference]
23003-30-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [HS Code ]
29333999 |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow to yellow powder | [Synthesis]
Step A: 6-Methylpyridin-3-ol (0.5 g, 4.58 mmol) was dissolved in aqueous sodium hydroxide solution (4.5 mL, 1 M, 4.5 mmol). Iodine (1.28 g, 5.2 mmol) was added to this solution and the reaction mixture was stirred overnight at room temperature. After completion of the reaction, it was neutralized with aqueous hydrochloric acid (2 M) to pH ≈ 7. A white precipitate precipitated from the reaction system and the product was collected by filtration. The solid product was washed with deionized water and dried to give 2-iodo-6-methylpyridin-3-ol (0.8 g, 50% yield). Mass spectral analysis showed m/z 236.0 [M + H]+. | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 16, p. 2117 - 2122
[2] Patent: US9617268, 2017, B2. Location in patent: Page/Page column 400; 401
[3] Patent: EP1477186, 2004, A1. Location in patent: Page/Page column 35; 36
[4] Patent: EP1357111, 2003, A1. Location in patent: Page/Page column 54
[5] Tetrahedron, 2007, vol. 63, # 13, p. 2787 - 2797 |
|
|