| Identification | Back Directory | [Name]
(S,R,S)-AHPC-C6-NH2 | [CAS]
2306389-03-5 | [Synonyms]
(S,R,S)-AHPC-C6-NH2
PROTACs Related Compound 3
(2S,4R)-1-((S)-2-(7-aminoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide | [Molecular Formula]
C29H43N5O4S | [MOL File]
2306389-03-5.mol | [Molecular Weight]
557.75 |
| Chemical Properties | Back Directory | [Boiling point ]
834.4±65.0 °C(Predicted) | [density ]
1.200±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
14.08±0.40(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
(S,R,S)-AHPC-C6-NH2 is a E3 ligase ligand-linker conjugate that is comprised of the (S,R,S)-AHPC based VHL ligand and a six carbon alkane linker used for EED-Targeted PROTAC. | [Uses]
(S,R,S)-AHPC-C6-NH2 (VH032-C6-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in?PROTAC?technology[1]. | [IC 50]
VHL | [References]
[1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery.?Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
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