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2341796-74-3

2341796-74-3 Structure

2341796-74-3 Structure
IdentificationBack Directory
[Name]

VH032-C10-NH2
[CAS]

2341796-74-3
[Synonyms]

VH032-C10-NH2
S)-AHPC-C10-NH2
(S,R,S)-AHPC-C10-NH2
PROTACs Related Compound 5
(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2)
L-Prolinamide, N-(11-amino-1-oxoundecyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
[Molecular Formula]

C33H51N5O4S
[MDL Number]

MFCD33029234
[MOL File]

2341796-74-3.mol
[Molecular Weight]

613.85
Chemical PropertiesBack Directory
[Boiling point ]

852.5±65.0 °C(Predicted)
[density ]

1.156±0.06 g/cm3(Predicted)
[pka]

14.08±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC[1].
[IC 50]

VHL
[References]

[1] Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31. DOI:10.1002/cmdc.201900497
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