| Identification | Back Directory | [Name]
[1,4'-Bipiperidine]-1'-carboxylic acid, 4-[2-(4-carboxyphenyl)ethynyl]-, 1'-(1,1-dimethylethyl) ester | [CAS]
2308497-81-4 | [Synonyms]
Boc-bipiperidine-ethynylbenzoic acid
[1,4'-Bipiperidine]-1'-carboxylic acid, 4-[2-(4-carboxyphenyl)ethynyl]-, 1'-(1,1-dimethylethyl) ester | [Molecular Formula]
C24H32N2O4 | [MOL File]
2308497-81-4.mol | [Molecular Weight]
412.52 |
| Chemical Properties | Back Directory | [Boiling point ]
557.5±50.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
4.10±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Boc-bipiperidine-ethynylbenzoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of ARD-61[1]. Boc-bipiperidine-ethynylbenzoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Alkyl/ether | [References]
[1] Lijie Zhao, et al. A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivo. Neoplasia. 2020 Oct;22(10):522-532. DOI:10.1016/j.neo.2020.07.002 |
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