| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:20.07(Max Conc. mg/mL);50.01(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);24.92(Max Conc. mM) | [form ]
A crystalline solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
LDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively[1]. | [IC 50]
DYRK1; DYRK2 | [storage]
Store at -20°C | [References]
[1] Cuny GD, et al. Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3491-4. PMID:20836251
[2] Gregory D Cuny, et al. Structure-activity Relationship Study of Acridine Analogs as Haspin and DYRK2 Kinase Inhibitors. Bioorg Med Chem Lett DOI:10.2174/0929867324666170414155520 |
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