2309172-48-1
2309172-48-1 结构式
物理化学性质
PBS (pH 7.2):10.0(Max Conc. mg/mL);24.92(Max Conc. mM)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-13455A | LDN-192960 HYDROCHLORIDE LDN-192960 hydrochloride | 2309172-48-1 | 1 mg | 1333元 |
| 2025/02/08 | HY-13455A | LDN-192960 HYDROCHLORIDE LDN-192960 hydrochloride | 2309172-48-1 | 5mg | 2000元 |
| 2025/02/08 | HY-13455A | LDN-192960 HYDROCHLORIDE LDN-192960 hydrochloride | 2309172-48-1 | 10mg | 3200元 |
常见问题列表
IC50: 10 nM (Haspin); 48 nM (DYRK2)
LDN-192960 hydrochloride (10 μM) is selective and inhibits ten of the other kinases by ≥90%, with only five being potently inhibited (IC 50 <1 μM), including CLK1 (IC 50 =0.21 μM), DYRK1A (IC 50 = 0.10 μM), DYRK2 (IC 50 =2 nM), DYRK3 (IC 50 =19 nM) and PIM1 (IC 50 =0.72 μM).LDN-0192960 hydrochloride (0-5 μM; 2 hours) demonstrates that the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells overexpressing Haspin with an EC 50 of 1.17 μM.LDN-0192960 hydrochloride (0-1 μM; 1 hour incubation in the presence of nocodazole and MG132) demonstrates the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells synchronized in mitosis with an EC 50 of 0.02 μM.