| Identification | Back Directory | [Name]
1,2,5-Oxadiazole-3-carboximidamide, N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[[2-[4-[(2-hydroxyethoxy)methyl]-1H-1,2,3-triazol-1-yl]ethyl]amino]- | [CAS]
2310286-45-2 | [Synonyms]
IDO1/2-IN-1
1,2,5-Oxadiazole-3-carboximidamide, N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[[2-[4-[(2-hydroxyethoxy)methyl]-1H-1,2,3-triazol-1-yl]ethyl]amino]- | [Molecular Formula]
C16H18BrFN8O4 | [MOL File]
2310286-45-2.mol | [Molecular Weight]
485.27 |
| Chemical Properties | Back Directory | [Boiling point ]
735.0±70.0 °C(Predicted) | [density ]
1.78±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
7.65±0.69(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
IDO1/2-IN-1 (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 exhibits antitumor activies. Orally active[1]. | [IC 50]
IDO1: 28 nM (IC50); IDO2: 144 nM (IC50) | [References]
[1] He X, et al. Discovery of the First Potent IDO1/IDO2 Dual Inhibitors: A Promising Strategy for Cancer Immunotherapy. J Med Chem. 2021;64(24):17950-17968. DOI:10.1021/acs.jmedchem.1c01305 |
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