| Identification | Back Directory | [Name]
VH032-O-Ph-PEG1-NH2 | [CAS]
2361117-24-8 | [Synonyms]
VH032-O-Ph-PEG1-NH2
(S,R,S)-AHPC-O-Ph-PEG1-NH2 | [Molecular Formula]
C32H41N5O6S | [MDL Number]
MFCD33029231 | [MOL File]
2361117-24-8.mol | [Molecular Weight]
623.77 |
| Chemical Properties | Back Directory | [Boiling point ]
919.7±65.0 °C(Predicted) | [density ]
1.270±0.06 g/cm3(Predicted) | [solubility ]
DMSO : 100 mg/mL (160.32 mM; Need ultrasonic) | [form ]
Solid | [pka]
13.43±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) is E3 ligase ligand-linker conjugate and incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-O-Ph-PEG1-NH2 is used in PROTAC EED degrader-1 (HY-130614). PROTAC EED degrader-1 is a PROTAC targeting EED with a pKD of 9.02[1]. | [IC 50]
VHL | [References]
[1] Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9. DOI:10.1016/j.chembiol.2019.11.004 |
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