| Identification | Back Directory | [Name]
Hydrazinecarboxamide, 2-[1-(2,4-dihydroxy-3-methylphenyl)propylidene]-N-[(3-hydroxyphenyl)methyl]- | [CAS]
2351906-74-4 | [Synonyms]
GA-017
Hydrazinecarboxamide, 2-[1-(2,4-dihydroxy-3-methylphenyl)propylidene]-N-[(3-hydroxyphenyl)methyl]- | [Molecular Formula]
C18H21N3O4 | [MOL File]
2351906-74-4.mol | [Molecular Weight]
343.38 |
| Chemical Properties | Back Directory | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 20.83 mg/mL (60.66 mM; ultrasonic and warming and heat to 80°C) | [form ]
Solid | [pka]
8.70±0.45(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids[1]. | [Biological Activity]
GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids[1].
GA-017 suppresses the cell death of HUVECs and promotes their cell growth[1].GA-017 facilitates SKOV3 cell growth, with an EC50 of 3.51 ± 0.26 μM[1].GA-017 competitively inhibited LATS1 and 2 against ATP, with Ki (inhibition constant) values of 0.58 ± 0.11 and 0.25 ± 0.03 nM, respectively[1]. | [IC 50]
YAP/TAZ | [References]
[1]. Aihara A, et al. Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions. J Biol Chem. 2022 Apr;298(4):101779. |
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