| Identification | Back Directory | [Name]
Pyrimido[4,5-b]quinoline-8-carbonitrile, 2,3,4,10-tetrahydro-2,4-dioxo-10-[4-(phenylmethoxy)phenyl]- | [CAS]
2351940-23-1 | [Synonyms]
Pyrimido[4,5-b]quinoline-8-carbonitrile, 2,3,4,10-tetrahydro-2,4-dioxo-10-[4-(phenylmethoxy)phenyl]- | [Molecular Formula]
C25H16N4O3 | [MOL File]
2351940-23-1.mol | [Molecular Weight]
420.42 |
| Chemical Properties | Back Directory | [density ]
1.35±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
5.09±0.20(predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
ZW-1226 is a selective inhibitor of MRP1, reducing the uptake activity of MRP1 vesicles by 65?% at 5 μM. ZW-1226 shows inhibition of MRP1 in a GSH dependent way and good selectivity for MRP1 over other major ABC transporters, including P-gp, BCRP, MRP2 and MRP3[1]. | [References]
[1] Zakia Belhadj, et al. Characterization of a deazaflavin analog as a potent inhibitor of multidrug resistance-associated protein 1. Biomed Pharmacother. 2024 Jul 19:178:117167. DOI:10.1016/j.biopha.2024.117167 |
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