| Chemical Properties | Back Directory | [Boiling point ]
686.5±55.0 °C(Predicted) | [density ]
1.15±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [pka]
4.28±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
TCO-PEG8-acid is a very reactive click chemistry reagent. The terminal carboxylic acid (CO2H) can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable bond. TCO moiety is reactive with tetrazine-containing compounds to form a stable bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
TCO-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. DOI:10.1016/j.apsb.2019.08.001 |
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