| Identification | More | [Name]
4-Bromo-2-fluoroanisole | [CAS]
2357-52-0 | [Synonyms]
1-BROMO-3-FLUORO-4-METHOXYBENZENE
2-FLUORO-4-BROMOANISOLE
4-BROMO-2-FLUOROANISOLE
4-Bromo-2-fluoro-1-methoxybenzene
Benzene, 4-bromo-2-fluoro-1-methoxy-
4-Bromo-2-Fluoromethoxybenzene
4-Bromo-2-Fluoroanisole 2-Fluoro-4-Bromoanisole
2-Fluoro-4-Bromo Anisol
4-Bromo-2-fluoroanisole, 97+%
4-Bromo-2-fluoroanisole, 99+%
4-Bromo-2-fluoroanisole 98%
4-Bromo-2-fluoroanisole98%
4-Cyano-fluoro phenol
1-Methoxy-2-fluoro-4-bromobenzene | [EINECS(EC#)]
219-096-2 | [Molecular Formula]
C7H6BrFO | [MDL Number]
MFCD00011710 | [Molecular Weight]
205.02 | [MOL File]
2357-52-0.mol |
| Chemical Properties | Back Directory | [Appearance]
CLEAR VERY SLIGHTLY YELLOW LIQUID | [Melting point ]
16 °C
| [Boiling point ]
84 °C/7 mmHg (lit.) | [density ]
1.59 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.545(lit.)
| [Fp ]
209 °F
| [storage temp. ]
Sealed in dry,Room Temperature | [form ]
clear liquid | [color ]
Colorless to Light yellow | [Specific Gravity]
1.590 | [Water Solubility ]
insoluble | [BRN ]
3240714 | [InChI]
InChI=1S/C7H6BrFO/c1-10-7-3-2-5(8)4-6(7)9/h2-4H,1H3 | [InChIKey]
DWNXGZBXFDNKOR-UHFFFAOYSA-N | [SMILES]
C1(OC)=CC=C(Br)C=C1F | [CAS DataBase Reference]
2357-52-0(CAS DataBase Reference) | [NIST Chemistry Reference]
4-Bromo-2-fluoroanisole(2357-52-0) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29093090 | [Storage Class]
10 - Combustible liquids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
CLEAR VERY SLIGHTLY YELLOW LIQUID | [Uses]
4-Bromo-2-fluoroanisole has been used in the synthesis of:
- 1,4-bis[(3′-fluoro-4′-n alkoxyphenyl)ethynyl]benzenes with n=1-12
- 7-fluoro-6-methoxy-1-methyl-2-naphthaldehyde
- 5,7-difluoro-6-methoxy-1-methyl-2-naphthaldehyde
- liquid crystals with terminal difluoromethoxy group and backbone of phenylbicyclohexane
| [General Description]
The IR and FT-IR spectra of 4-bromo-2-fluoroanisole have been investigated. | [Synthesis]
(a) Synthesis of 2-fluoro-4-bromoanisole: Add 128 g (1.016 mol) of 2-fluoroanisole and 250 ml of chloroform to the reaction vessel. Under stirring conditions at room temperature, 177 g (1.106 mol) of bromine was slowly added dropwise for not less than 3 hours. Upon completion of the reaction, the reaction mixture was poured into dilute aqueous sodium hydroxide solution to separate the chloroform layer. The chloroform layer was subsequently washed with saturated sodium chloride solution and dried with anhydrous sodium sulfate. The solvent was removed by distillation and the residue was distilled under reduced pressure to give 2-fluoro-4-bromoanisole. The yield was 192 g (yield: 92.3%) and the boiling point was 107°-116°C (25-31 mmHg). | [References]
[1] Journal of Organic Chemistry, 2018, vol. 83, # 2, p. 930 - 938
[2] Patent: US5098602, 1992, A
[3] Helvetica Chimica Acta, 1984, vol. 67, p. 1572 - 1579
[4] Patent: US5397504, 1995, A
[5] Patent: US4997942, 1991, A |
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