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2378173-15-8

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2378173-15-8 Structure

2378173-15-8 Structure
IdentificationBack Directory
[Name]

Cyclohexanecarboxylic acid, 2-[[(7-hydroxy-5-phenylpyrazolo[1,5-a]pyrimidin-3-yl)carbonyl]amino]-, (1R,2S)-
[CAS]

2378173-15-8
[Synonyms]

Cyclohexanecarboxylic acid, 2-[[(7-hydroxy-5-phenylpyrazolo[1,5-a]pyrimidin-3-yl)carbonyl]amino]-, (1R,2S)-
[Molecular Formula]

C20H20N4O4
[MDL Number]

MFCD31697699
[MOL File]

2378173-15-8.mol
[Molecular Weight]

380.4
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 30 mg/ml
[form ]

A solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 μΜ. PF-06928215 has a high binding affinity of 0.2 μM (Kd)[1].
[Biological Activity]

PF-06928215 is a high-affinity cGAS (cyclic GMP-AMP Synthase) inhibitor with IC50 of 4.9 μM and affinity Kd value of 0.2 μM.
[in vitro]

PF-06928215 displays no activity in cellular cGAS assays measuring dsDNA-induced IFN-beta expression.

[storage]

Store at -20°C
[References]

[1] Hall J, et al. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS One. 2017 Sep 21;12(9):e0184843. DOI:10.1371/journal.pone.0184843
Spectrum DetailBack Directory
[Spectrum Detail]

PF-06928215(2378173-15-8)1HNMR
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