| Identification | Back Directory | [Name]
3-Butyn-2-ol, 4-[3-[[[2-amino-5-[2-(4-piperidinyl)-5-thiazolyl]-3-pyridinyl]oxy]methyl]phenyl]-2-methyl- | [CAS]
2380300-99-0 | [Synonyms]
3-Butyn-2-ol, 4-[3-[[[2-amino-5-[2-(4-piperidinyl)-5-thiazolyl]-3-pyridinyl]oxy]methyl]phenyl]-2-methyl- | [Molecular Formula]
C25H28N4O2S | [MOL File]
2380300-99-0.mol | [Molecular Weight]
448.58 |
| Chemical Properties | Back Directory | [Boiling point ]
657.8±55.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.05±0.29(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
HPK1-IN-34 (Compound 143) is a Hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 of <100 nM[1]. HPK1-IN-34 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
HPK1: <100 nM (IC50) | [References]
[1] Xuebin Liao, et al. Hpk1 inhibitors, preparation method and application thereof. Patent WO2019206049A1. |
|
|