| Identification | Back Directory | [Name]
Thalidomide-O-PEG3-amine HCl | [CAS]
2387510-82-7 | [Synonyms]
Thalidomide-O-PEG3-amine HCl
Thalidomide-PEG4-NH2 (hydrochloride)
Thalidomide-O-PEG3-amine hydrochloride | [MDL Number]
MFCD32861322 | [MOL File]
2387510-82-7.mol | [Molecular Weight]
485.92 |
| Hazard Information | Back Directory | [Uses]
Thalidomide-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. | [Biological Activity]
Thalidomide 4'-ether-PEG3-amine is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus a short PEG linker ready for conjugation to a target protein ligand. This product has been recently renamed. The previous name for this product was Thalidomide - linker 11 | [IC 50]
Cereblon | [storage]
Store at -20°C | [References]
[1] Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.??[Content Brief] DOI:10.1038/nature13527 |
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