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1957235-91-4

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1957235-91-4 Structure

1957235-91-4 Structure
IdentificationBack Directory
[Name]

4-((8-Aminooctyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
[CAS]

1957235-91-4
[Synonyms]

Thalidomide-O-C8-NH2
4-((8-Aminooctyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
[Molecular Formula]

C21H27N3O5
[MDL Number]

MFCD32063458
[MOL File]

1957235-91-4.mol
[Molecular Weight]

401.46
Chemical PropertiesBack Directory
[Boiling point ]

639.9±55.0 °C(Predicted)
[density ]

1.274±0.06 g/cm3(Predicted)
[pka]

10.70±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

Thalidomide-4-O-C8-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
[IC 50]

Cereblon
[References]

[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1008. DOI:10.1016/j.cell.2020.07.024
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