| Identification | Back Directory | [Name]
Acetamide, 2-[(7-bromo-6-methoxy-1H-indol-3-yl)thio]-N-(2-ethoxyphenyl)- | [CAS]
2395007-81-3 | [Synonyms]
RSV/IAV-IN-3
Acetamide, 2-[(7-bromo-6-methoxy-1H-indol-3-yl)thio]-N-(2-ethoxyphenyl)- | [Molecular Formula]
C19H19BrN2O3S | [MOL File]
2395007-81-3.mol | [Molecular Weight]
435.33 |
| Hazard Information | Back Directory | [Uses]
RSV/IAV-IN-3 (compound 14'i) is a dual inhibitor of respiratory syncytial virus (RSV) and influenza A virus (IAV) with EC50 values of 2.92 μM and 1.90 μM,respectively. RSV/IAV-IN-3 has antiviral effect against H1N1 and H3N2 with EC50 values of 3.25 μM and 1.50 μM in MDCK cells, respectively. RSV/IAV-IN-3 significantly inhibits the activity of luciferase in a dose-dependent manner, with an EC50 of 3.89 μM. RSV/IAV-IN-3 inhibits IAV infectivity and RdRp activity. RSV/IAV-IN-3 inhibits IAV and RSV replication at the post-entry stage[1]. | [References]
[1] Guo-Ning Zhang, et al. Design and synthesis of 2-((1H-indol-3-yl)thio)-N-phenyl-acetamides as novel dual inhibitors of respiratory syncytial virus and influenza virus A. Eur J Med Chem. 2020 Jan 15;186:111861. DOI:10.1016/j.ejmech.2019.111861 |
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