| Identification | Back Directory | [Name]
Sulfamic acid, 4-[1-(3,5-dichlorophenyl)-1H-1,2,3-triazol-4-yl]phenyl ester | [CAS]
2403716-19-6 | [Synonyms]
Steroid sulfatase-IN-1
Sulfamic acid, 4-[1-(3,5-dichlorophenyl)-1H-1,2,3-triazol-4-yl]phenyl ester | [Molecular Formula]
C14H10Cl2N4O3S | [MOL File]
2403716-19-6.mol | [Molecular Weight]
385.23 |
| Hazard Information | Back Directory | [Uses]
Steroid sulfatase-IN-1 is a potent and orally active Steroid sulfatase inhibitor with an IC50 of 1.71 nM. Steroid sulfatase-IN-1 shows antitumor activity in vivo. Steroid sulfatase-IN-1 has the potential for the research of breast cancer[1]. | [in vivo]
Steroid sulfatase-IN-1 (compound 4 b) (50 mg/kg; p.o.) shows significant antitumor activity in Breast Carcinoma Model[1]. | Animal Model: | 67NR mouse (Breast Carcinoma Model)[1] | | Dosage: | 50 mg/kg | | Administration: | P.o. | | Result: | Showed significant antitumor activity with the TGI value of 51%. |
| [References]
[1] Biernacki K, et al. Development of Sulfamoylated 4-(1-Phenyl-1H-1,2,3-triazol-4-yl)phenol Derivatives as Potent Steroid Sulfatase Inhibitors for Efficient Treatment of Breast Cancer. J Med Chem. 2022; 65(6):5044-5056. DOI:10.1021/acs.jmedchem.1c02220 |
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