| Identification | Back Directory | [Name]
Oxirane, 2-[[3,4-bis[(4-fluorophenyl)methoxy]phenoxy]methyl]-, (2R)- | [CAS]
2409960-12-7 | [Synonyms]
(R)-2-((3,4-bis((4-fluorobenzyl)oxy)phenoxy)methyl)oxirane
Oxirane, 2-[[3,4-bis[(4-fluorophenyl)methoxy]phenoxy]methyl]-, (2R)- | [Molecular Formula]
C23H20F2O4 | [MOL File]
2409960-12-7.mol | [Molecular Weight]
398.4 |
| Hazard Information | Back Directory | [Uses]
YT 6-2 analog-1 (compound 2-3) is the p62/SQSTM1 targeting, autophagy-targeting ligand (ATL) of AUTOTAC ATC-324 (HY-169385), which is an bivalent AR (Androgen Receptor) degrader. ATC-324 can reduce nuclear AR levels and downregulate target gene expression of AR and AR-v7, and also has a degradation effect on common AR mutants in PCa[1]. | [References]
[1] Bae TH, et al. An Autophagy-Targeting Chimera Induces Degradation of Androgen Receptor Mutants and AR-v7 in Castration-Resistant Prostate Cancer. Cancer Res. 2024 Nov 12. DOI:10.1158/0008-5472.CAN-24-0591 |
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