| Identification | Back Directory | [Name]
Benzenebutanamide, N-[(14R)-15-[3,4-bis(phenylmethoxy)phenoxy]-14-hydroxy-3,6,9-trioxa-12-azapentadec-1-yl]- | [CAS]
2410081-55-7 | [Synonyms]
Benzenebutanamide, N-[(14R)-15-[3,4-bis(phenylmethoxy)phenoxy]-14-hydroxy-3,6,9-trioxa-12-azapentadec-1-yl]- | [Molecular Formula]
C41H52N2O8 | [MOL File]
2410081-55-7.mol | [Molecular Weight]
700.86 |
| Chemical Properties | Back Directory | [Boiling point ]
850.2±65.0 °C(predicted) | [density ]
1.155±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
13.79±0.20(predicted) |
| Hazard Information | Back Directory | [Uses]
PBA-1106 is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1106 increases the autophagic flux of Ub-conjugated aggregates[1]. | [References]
[1] Chang Hoon Ji, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13(1):904. DOI:10.1038/s41467-022-28520-4 |
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