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TLR7 agonist 17 (compound 20) is a potent TLR7 agonist with EC50 values of 12 nM and 17 nM for hTLR7 and mTLR7, respectively. TLR7 agonist 17 shows anticancer activity[1]. | [IC 50]
human TLR7: 12 nM (EC50); mTLR7: 17 nM (EC50) | [References]
[1] Yam B. Poudel, et al. Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology. CS Med. Chem. Lett. 2024. |
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