| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
2412056-48-3 | [Synonyms]
Thalidomide-NH-PEG4-COOH
1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-3,6,9,12-tetraoxapentadecan-15-oic acid | [Molecular Formula]
C24H31N3O10 | [MOL File]
2412056-48-3.mol | [Molecular Weight]
521.52 |
| Chemical Properties | Back Directory | [Boiling point ]
773.6±60.0 °C(Predicted) | [density ]
1.385±0.06 g/cm3(Predicted) | [solubility ]
DMSO : 80 mg/mL (153.40 mM; Need ultrasonic) | [form ]
Solid-Liquid Mixture | [pka]
4.28±0.10(Predicted) | [color ]
Yellow to green |
| Hazard Information | Back Directory | [Uses]
Thalidomide-NH-PEG4-COOH is an E3 ligase ligand-linker conjugate which can be used for synthesizing dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP[1]. | [Biological Activity]
Thalidomide-NH-PEG4-COOH is an E3 ligase ligand-linker conjugate which can be used for synthesizing dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP[1].
Thalidomide-NH-PEG4-COOH (S13) is the E3 ligase ligand-linker conjugate of dCBP-1[1]. | [IC 50]
Cereblon | [References]
[1]. Raghu Vannam, et al. Targeted degradation of the enhancer lysine acetyltransferases CBP and p300. Cell Chem Biol. 2020 Dec 31;S2451-9456(20)30513-4. |
|
|