| Identification | Back Directory | [Name]
Pomalidomide-PEG3-CO2H | [CAS]
2138440-82-9 | [Synonyms]
Pomalidomide-PEG3-CO2H
Pomalidomide-PEG3-COOH
POMALIDOMIDE-PEG 3-CO 2 H
Pomalidomide-PEG3-CO2H >=95%
3-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)propanoic acid
3-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]propanoic acid
Propanoic acid, 3-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]- | [Molecular Formula]
C22H27N3O9 | [MDL Number]
MFCD32173779 | [MOL File]
2138440-82-9.mol | [Molecular Weight]
477.46 |
| Chemical Properties | Back Directory | [Boiling point ]
757.8±60.0 °C(Predicted) | [density ]
1.417±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
4.28±0.10(Predicted) | [color ]
Light yellow to green yellow | [InChI]
1S/C22H27N3O9/c26-17-5-4-16(20(29)24-17)25-21(30)14-2-1-3-15(19(14)22(25)31)23-7-9-33-11-13-34-12-10-32-8-6-18(27)28/h1-3,16,23H,4-13H2,(H,27,28)(H,24,26,29) | [InChIKey]
QBYOEHKZQIFBGV-UHFFFAOYSA-N | [SMILES]
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCOCCOCCOCCC(O)=O)=O)NC1=O |
| Hazard Information | Back Directory | [Uses]
Protein degrader builiding block Pomalidomide-PEG3-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. | [reaction suitability]
reactivity: amine reactive
reagent type: ligand-linker conjugate | [IC 50]
Cereblon | [storage]
Store at -20°C |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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