| Identification | Back Directory | [Name]
CARBOXYPYRIDOSTATIN TRIFLUOROACETATE SALT | [CAS]
2444713-88-4 | [Synonyms]
CARBOXYPYRIDOSTATIN TRIFLUOROACETATE SALT | [Molecular Formula]
C37H35F3N10O9 | [MDL Number]
MFCD28580124 | [MOL File]
2444713-88-4.mol | [Molecular Weight]
820.74 |
| Hazard Information | Back Directory | [Uses]
Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand. Carboxy pyridostatin trifluoroacetate salt has a highly molecular specificity to RNA on DNA G4s and reduces ATF-5 protein. Carboxy pyridostatin trifluoroacetate salt reduces cell proliferation and hinders stress granule (SG) formation[1][2][3]. | [in vivo]
Carboxy pyridostatin trifluoroacetate salt (10 mg/kg; i.p.; every 12 h; 3 injections) significantly reduces the number of PCNA-expressing cells in the adult SVZ and increases the number of OLIG2-expressing cells in the corpus callosum in mice[1].
| Animal Model: | C57BL/6 mice (both sexes, 1-2 months old)[1] | | Dosage: | 10 mg/kg (dissolved in phosphate-buffered saline) | | Administration: | Intraperitoneal injection, every 12 h, 3 injections | | Result: | Reduced the number of PCNA-expressing cells in the adult SVZ of mice, indicating a decrease in cell proliferation.
Increased the number of OLIG2-expressing cells in the corpus callosum.
Showed no increase in OLIG2-expression in the SVZ.
Affected the differentiation of neural stem and progenitor cells in different brain regions.
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| [References]
[1] Goldberg DC, et al. Manipulating Adult Neural Stem and Progenitor Cells with G-Quadruplex Ligands. ACS Chem Neurosci. 2020;11(10):1504-1518. DOI:10.1021/acschemneuro.0c00194
[2] Rocca R, et al. Molecular recognition of a carboxy pyridostatin toward G-quadruplex structures: Why does it prefer RNA? Chem Biol Drug Des. 2017 Nov;90(5):919-925. DOI:10.1111/cbdd.13015
[3] Turner M, et al. rG4detector, a novel RNA G-quadruplex predictor, uncovers their impact on stress granule formation. Nucleic Acids Res. 2022 Nov 11;50(20):11426-11441. DOI:10.1093/nar/gkac950 |
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