| Identification | More | [Name]
Phthalazine | [CAS]
253-52-1 | [Synonyms]
2,3-BENZODIAZINE
4,5-BENZOPYRIDAZINE
BENZO[D]PYRIDAZINE
PHTHALAZINE
PHZ
2,3-Diazanaphthalene
beta-Phenodiazine
β-Phenodiazine
Phthalazine~99%
4,5-Benzo-1,2-diazine | [EINECS(EC#)]
205-963-2 | [Molecular Formula]
C8H6N2 | [MDL Number]
MFCD00006908 | [Molecular Weight]
130.15 | [MOL File]
253-52-1.mol |
| Chemical Properties | Back Directory | [Appearance]
SLIGHTLY BROWN TO BEIGE CRYSTALLINE POWDER | [Melting point ]
89-92 °C(lit.) | [Boiling point ]
189 °C29 mm Hg(lit.) | [density ]
1.1509 (rough estimate) | [refractive index ]
1.6231 (estimate) | [Fp ]
178-180°C/15mm | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Crystalline Powder | [pka]
3.47(at 20℃) | [color ]
Slightly brown to beige | [Water Solubility ]
Soluble in water, methanol, chloroform. | [Merck ]
14,7370 | [BRN ]
109240 | [InChI]
1S/C8H6N2/c1-2-4-8-6-10-9-5-7(8)3-1/h1-6H | [InChIKey]
LFSXCDWNBUNEEM-UHFFFAOYSA-N | [SMILES]
c1ccc2cnncc2c1 | [CAS DataBase Reference]
253-52-1(CAS DataBase Reference) | [NIST Chemistry Reference]
Phthalazine(253-52-1) | [EPA Substance Registry System]
253-52-1(EPA Substance) |
| Questions And Answer | Back Directory | [Preparation]
2,3-diazanaphthalene can be obtained by reacting 1-(2H)-phthalazinone with phosphorus oxychloride to generate 1-chlorophthalazine, and then reacting it with hydrazine hydrate. |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS08 | [Signal word ]
Warning | [Hazard statements ]
H341-H412 | [Precautionary statements ]
P202-P273-P280-P308+P313-P405-P501 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S37/39:Wear suitable gloves and eye/face protection .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [TSCA ]
Yes | [HS Code ]
29339900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Aquatic Chronic 3
Muta. 2 |
| Hazard Information | Back Directory | [Chemical Properties]
SLIGHTLY BROWN TO BEIGE CRYSTALLINE POWDER | [Uses]
Phthalazine derivatives including copper and platinum complexes were induce the apoptosis in breast cancer cell lines and renal hyperemia. | [Uses]
Phthalazine is a heterocyclic organic compound isomeric with quinoxaline, cinnoline and quinazoline. Aminophthalazine compounds serve as effective phosphodiesterase (PDE) inhibitors. | [Definition]
ChEBI: An azaarene that is the 2,3-diaza analogue of naphthalene. The parent of the class of phthalazines. | [Synthesis Reference(s)]
Journal of Heterocyclic Chemistry, 2, p. 206, 1965 DOI: 10.1002/jhet.5570020219 | [Purification Methods]
Phthalazine crystallises from diethyl ether or *benzene, and sublimes under a vacuum. The hydrochloride forms needles from EtOH with m 235-236o(dec) and the picrate has m 208-210o. [Armarego J Appl Chem 11 70 1961, Beilstein 23 H 174, 23 III/IV 1233.] |
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J & K SCIENTIFIC LTD.
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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