| Identification | Back Directory | [Name]
(1alpha,3beta,22R)-3-[(6-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy]-1,22-dihydroxyergosta-5,24-dien-26-oic acid delta-lactone | [CAS]
256520-90-8 | [Synonyms]
Withanoside V
WITHANOSIDE V(SH)
Withanoside V 256520-90-8
(1α,3β,22R)-3-[(6-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]-1,22-dihydroxy-ergosta-5,24-dien-26-oic acid δ-lactone
Ergosta-5,24-dien-26-oic acid, 3-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-1,22-dihydroxy-, δ-lactone, (1α,3β,22R)-
(1alpha,3beta,22R)-3-[(6-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy]-1,22-dihydroxyergosta-5,24-dien-26-oic acid delta-lactone | [Molecular Formula]
C40H62O14 | [MDL Number]
MFCD09264638 | [MOL File]
256520-90-8.mol | [Molecular Weight]
766.91 |
| Chemical Properties | Back Directory | [Boiling point ]
935.2±65.0 °C(Predicted) | [density ]
1.39 | [storage temp. ]
2-8°C | [solubility ]
DMSO: Soluble: = 10 mg/ml | [form ]
solid | [pka]
12.89±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Withanoside V is a withanolide derivative isolated from the roots of Withania somnifera. Withania somnifera L. Dunal (Solanaceae), also known as ''ashwagandha'' in Sanskrit and as ''Indian ginseng'', is used widely in Ayurvedic medicine as a nerve tonic and memory enhancer, with antiaging, antistress, immunomodulatory and antioxidant properties. | [References]
[1] BOLLEDDULA JAYAPRAKASAM Muraleedharan G N Gale A Strasburg. Potent lipid peroxidation inhibitors from Withania somnifera fruits[J]. Tetrahedron, 2004, 60 13: Pages 3109-3121. DOI: 10.1016/j.tet.2004.01.016
[2] SHREYA DUBEY Rajagopal S Monika Kallubai. Improving the inhibition of β-amyloid aggregation by withanolide and withanoside derivatives[J]. International Journal of Biological Macromolecules, 2021, 173: Pages 56-65. DOI: 10.1016/j.ijbiomac.2021.01.094
[3] RAJKUMAR SINGH KALRA. COVID19-inhibitory activity of withanolides involves targeting of the host cell surface receptor ACE2: insights from computational and biochemical assays.[J]. Journal of Biomolecular Structure & Dynamics, 2022: 7885-7898. DOI: 10.1080/07391102.2021.1902858 |
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