| Identification | Back Directory | [Name]
WITHANOLIDE B(P)(NEW) | [CAS]
56973-41-2 | [Synonyms]
Withanolide B
WITHANOLIDE B(SH)
Lycium substance B
WITHANOLIDE B(P)(NEW)
WITHANOLIDE B(SH)(NEW)
Withanolide B 56973-41-2
(5a,6a,7a,22R)-6,7-Epoxy-5,22-dihydroxy-1-oxoergosta-2,24-dien-26-oic acid d-lactone
(5α,6α,7α,22R)-6,7-Epoxy-5,22-dihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid δ-lactone
Ergosta-2,24-dien-26-oic acid, 6,7-epoxy-5,22-dihydroxy-1-oxo-, δ-lactone, (5α,6α,7α,22R)- | [Molecular Formula]
C28H38O5 | [MDL Number]
MFCD19053156 | [MOL File]
56973-41-2.mol | [Molecular Weight]
454.6 |
| Chemical Properties | Back Directory | [density ]
1.206 | [storage temp. ]
Store at -20°C | [solubility ]
Acetonitrile: 0.1 mg/ml; Methanol: 0.5 mg/ml | [form ]
neat | [color ]
White to off-white | [InChIKey]
ZTEVDTFJUUJBLP-MBMSZCMESA-N |
| Hazard Information | Back Directory | [Uses]
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects[1][2][3]. | [Definition]
ChEBI: Withanolide B is a withanolide. | [in vivo]
Withanolide B (10 mg/kg; topical administration) promotes bone healing in a rat tibial defect model[1]. | Animal Model: | Male Sprague-Dawley rats (8 weeks, 200 g) with tibial defect[1] | | Dosage: | 10 mg/kg | | Administration: | Injected in situ at the bone defect site at different time points (0, 3, 5, 7, and 9 days) | | Result: | Increased the trabecular number, trabecular thickness and the thickness of the cortical bone. |
| [storage]
Store at -20°C | [References]
[1] Kuang Z, et, al. Withanolide B promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via ERK1/2 and Wnt/β-catenin signaling pathways. Int Immunopharmacol. 2020 Nov;88:106960. DOI:10.1016/j.intimp.2020.106960
[2] Dubey S, et, al. Improving the inhibition of β-amyloid aggregation by withanolide and withanoside derivatives. Int J Biol Macromol. 2021 Mar 15;173:56-65. DOI:10.1016/j.ijbiomac.2021.01.094
[3] Sivanandha G, et, al. Enhanced biosynthesis of withanolides by elicitation and precursor feeding in cell suspension culture of Withania somnifera (L.) Dunal in shake-flask culture and bioreactor. PLoS One. 2014 Aug 4;9(8):e104005. DOI:10.1371/journal.pone.0104005 |
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www.bocsci.com |
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