| Identification | Back Directory | [Name]
1H-Indole-2-carboxamide, 5-chloro-N-[[1-(3-fluoro-4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]methyl]- | [CAS]
2582758-61-8 | [Synonyms]
MIF-IN-6
1H-Indole-2-carboxamide, 5-chloro-N-[[1-(3-fluoro-4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]methyl]- | [Molecular Formula]
C18H13ClFN5O2 | [MOL File]
2582758-61-8.mol | [Molecular Weight]
385.78 |
| Hazard Information | Back Directory | [Uses]
MIF-IN-6 (compound 2d) is a potent macrophage migration inhibitory factor (MIF) inhibitor with an IC50 of 1.4 μM and a Ki value of 0.96 μM, respectively. MIF-IN-6 attenuates MIF-induced ERK phosphorylation and inhibits proliferation of A549 cells[1]. | [References]
[1] Xiao Z, Fokkens M, Chen D, et al. Structure-activity relationships for binding of 4-substituted triazole-phenols to macrophage migration inhibitory factor (MIF). Eur J Med Chem. 2020;186:111849. DOI:10.1016/j.ejmech.2019.111849 |
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